Quantum sensing, defined as the use of a qubit system to measure environmental parameters, has been realized in a variety of physical platforms from alkali vapor cells to superconducting circuits. The nitrogen-vacancy defect in diamond is one realization amongst many and while there exist systems with better raw sensitivity metrics, the combination of room temperature operability, biocompatibility, and exceptional spatial resolution potentially enables the study of chemical and biological phenomena inaccessible to other platforms. In my talk, I will focus on using the nitrogen-vacancy defect to detect high resolution nuclear magnetic resonance signals from picoliter fluid analytes and address some of the technical hurdles that need to be overcome to directly compete with existing technologies.